Cancer microvessel Nano-material Blockage, CNB
When patients are treated with general chemotherapy, chemo medicine will naturally spread throughout the body. Unfortunately, the drug distribution is not limited to only cancerous areas, but healthy areas as well. For this reason, general chemo has such strong side effects, and is not particularly successful as a therapy. Therefore, we promote transarterial chemo-injection instead of systemic chemotherapy. In this procedure, we insert a catheter and give chemo medicine through the artery that supplies blood to the cancerous area. The advantage is a big increase in drug density inside cancer within a short period of time. The disadvantage is that the high drug density inside cancer is difficult to maintain, because the chemo medicine will eventually spread to the rest of the body along with blood. However, in this procedure, the side effects are less than the effects associated with systemic chemotherapy.
Cancer Microvessel Nano-material Blockage (CNB) combines different chemo medicines into a fine grain particle. By using superselective catheterization, this fine grain particle will be distributed inside the artery which supplies the target cancer. These fine grain particles of chemo medicine will stay inside tumor and maintain a high density for a long period of time. CNB is based on the following theory: there are a lot of gaps among the cancer capillary endothelial cells, and tight junctions among the normal capillary endothelial cells. The nano chemo particle will go inside the interstitial space of cancer, which causes an increase osmotic stress, and the differential pressure between artery and vein of tumor's blood capillary disappear. Thus, the blood flow will stop, and the fine grain particle will move slowly inside the tumor's blood capillary. Therefore, the chemo fine grain particle will stay for a relatively long time inside tumor. Meanwhile, because of the small size, there will not be embolism (blockage) in the normal capillary. Because we are able to use so much less chemo medicine, the side effects on the entire body are much less than with systemic chemotherapy.
Advantages of CNB
We compare the CNB with the general chemo for whole body.
There is an example which helps you understand the advantages of CNB.
If a patient weights 60kg and the tumor weights 50g(0.05kg)
General chemo
by vein infusionIf we give 15omg Oxaliplatin by vein infusion, there only is 0.125mg Oxaliplatin inside tumor,
others will inflow to other organs of body. Cancer microvessel