New Approaches May Prevent Certain Side Effects in BRAF Mutation-Positive MelanomaNovember 13, 2011 Recently discovered BRAF inhibitors may prevent drug-induced skin lesion side effects and lead to greater treatment durability.Mechanism of d...
Key Driver of Metastasis IdentifiedOctober 31, 2011 Protein S100A10 is essential for metastatic growth.Macrophages rely upon S100A10 to power movement of tumor cells to new sites. PHILADELPHIA Scientists at Dalhousie University in Nova Scoti...
Vaccine for Metastatic Breast, Ovarian Cancer Shows PromiseNovember 8, 2011 Vaccine is a recombinant poxviral compound.One patient with metastatic breast cancer had a sustained complete response.PHILADELPHIA Treatment with a recombinant poxv...
Combination Therapy Shows Potent Tumor Growth Inhibition in Preclinical StudiesNovember 13, 2011 VEGF and Ang2 are critical factors required for tumor angiogenesis.Combined blockade of VEGF and Ang2 with investigational agents enhances antit...
Antifolates Show Promise Against NSCLC SubtypeNovember 13, 2011 Aggressive lung cancers harboring KRAS mutations are sensitive to antifolates.Antifolates decrease KRAS gene expression.Large clinical trials needed to investigate antifolate ef...
Novel Monoclonal Antibody Offers Potential Treatment for Tumors Resistant to VEGF TherapyNovember 13, 2011 Shutting down the ALK-1 receptor inhibits the VEGF pathway.Response seen in patients who had used antiangiogenic therapy.VEGF therapie...
Researchers Develop More Effective Way to Discover and Test Potential Cancer DrugsNovember 13, 2011Phenotypic platform better predicts cancer drug effectiveness from the lab to actual tumors.Platform reduces time and money spent on drugs tha...
Ruling Blocking Graphic Cigarette Health Warnings Presents Major Setback for Public HealthNovember 9, 2011WASHINGTON, D.C. The American Association for Cancer Research strongly opposes the recent federal ruling that blocks implementation of...
Epigenetic Therapy Shows Promise in Hard-to-treat Lung CancerNovember 9, 2011 Therapy extended median survival to 6.4 months. Two patients are alive four years after start of epigenetic treatment.PHILADELPHIA Patients with recurrent metastat...
New Approaches May Prevent Certain Side Effects in BRAF Mutation-Positive MelanomaNovember 13, 2011 Recently discovered BRAF inhibitors may prevent drug-induced skin lesion side effects and lead to greater treatment durability.Mechanism of d...
