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Photodynamic Therapy (PDT)

Date:2009-06-29 16:17From:network Author:network Click:
Short Introduction Photodynamic therapy (PDT) is a special procedure for cancer which combines a drug (called a photosensitizer or photosensitizing agent) with a specific type of light to kill cancer cells Advantages Relatively selective an
  

Japan

  • Early stage oflung cancer
  • Superficial esophageal cancer
  • Superficial gastric cancer
  • Early cervical cancer and metaplastic proliferation

Canada

  • Obstructing esophageal cancer, unable to begiven Nd:YAG laser therapy
  • Early non-small cell lung cancer

Good effects showed by study

Barrett's esophagus with high-degree displasia and esophageal adenocarcinoma

Effective report from clinics

Early stage of carcinoma of oral cavity, tumor of head-neck, brain tumor, pleural or peritoneal mesothelioma, sarcoma in abdominal cavity, eye tumor, asophary geal cancer, tumor of chest wall, breast cancer, gynecologic cancer, rectal cancer, Kaposi sarcoma, skin cancer

Good prospects of application

Bone marrow, rheumatoid arthrositis, arteriolosclerosis, prevention of restricture after vascular plasticity, macula degeneration, streptococcus infection in peridentium, helicobacter pylori, wound infection.

Advantages
  • Relative selectivity and tissue speciality for tumor cells;
  • Low toxicity, good safety, no immunosuppression and marrow inhibition;
  • No bad effect on other therapies, complementary to surgery, radiotherapy and chemotherapy;
  • Short treatment time;
  • initiating therapeutic effectwithin 48-72 hours;

CLINICAL APPLICATION

Oral- pharygeal tumor

Early oral, nosal and nasopharygeal cancer: PDT had effective rates of 75%-100%.

Esophageal cancer

  • PDT had radical effect for early esophageal cancer;
  • PDT brings the five-year survival rate of 74%-84% in T1 and T2 stage of esophageal squamous and adenocarcinoma; PDT can effectively ameliorate obstruction of advanced esophageal carcinoma. Very effective for cervical esophageal cancer, Able to treat undermucosal disseminated and latent cancer. For cancer which grows into intracavity and stent has been placed, PDT can eradicate neoplasm in cavity.








 

Barrett esophagus

Normal squamous epithelium lining the esophagus is replaced by glandular columanar epithelium, that called Barrett esophagus, which increases the risk of esophageal adenocarcinoma. PDT not only can effectively eradicate Barrett epithelium, but has good result for early adenocarcinoma.

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Lung cancer

  • For lung cancer with bronchial obtruction, PDT induce improvement of air-way obstruction
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