Cancer microvessel Nano-material Blockage, CNB
When given the general chemo therapy, chemo medicine will go through all over the body. The drug distribution is not able to be neglected for the normal organ, however is limited for cancer. For this reason, the general chemo has a big side effect for the whole body, meanwhile is not able to deal with cancer very well. Therefore we chose the transarterial chemo-injection instead of chemo-therapy. We insert a catheter and give chemo medicine inside the artery which supplies blood for cancer. The advantage is a big increase of drug density inside cancer in a short time. While the disadvantage is the high drug density inside cancer can not keep working for a long time, because the chemo medicine will run away all over the body along with blood.
Cancer Microvessel Nano-material Blockage (CNB) combines different chemo medicines into fine grain particle by special technology firstly. Then the fine grain particle will be given inside the artery which supply target cancer by Superselective catheterization. This fine grain particle of chemo medicine will stay inside tumor and keep high density for long time. Theory for CNB is: there are a lot of gaps among the cancer capillary endothelial cells, while tight junction among the normal capillary endothelial cells. The nano chemo particle will go inside the interstitial space of cancer, which cause Osmotic stress increase, and the differential pressure between artery and vein of tumor's blood capillary disappear. So the blood flow will stop, and the fine grain particle will move slowly inside the tumor's blood capillary. Therefore the chemo fine grain particle will stay a long time inside tumor. Meanwhile, because of the small size, there will not be embolism in the normal capillary. And because we use much less chemo medicine, the side effect of the whole body is very small.
Advantages of CNB
We compare the CNB with the general chemo for whole body.
There is an example which helps you understand the advantages of CNB.
If a patient weights 60kg and the tumor weights 50g(0.05kg)
General chemo
by vein infusion If we give 15omg Oxaliplatin by vein infusion, there only is 0.125mg Oxaliplatin inside tumor,
others will inflow to other organs of body. Cancer microvessel
Nano-material Blockage Just 15mg Oxaliplatin by Superselective catheterization and intervention. For example two thirds(10mg)of the Oxaliplatin has inflowed to the blood flaw circulation, which only one third(5mg)of that remains in the target tumor tissue. The dose of chemo medicine inside tumor by CNB is